(SI10-062) Comprehensive Study on Methodology of Orthogonal Interleavers

Interleaving permutes the data bits by employing a user defined sequence to reduce burst error which at times exceeds the minimum hamming distance. It serves as the sole medium to distinguish user data in the overlapping channel and is the heart of Interleave Division Multiple Access (IDMA) scheme. Versatility of interleavers relies on various design parameters such as orthogonality, correlation, latency and performance parameters like bit error rate (BER), memory occupancy and computation complexity. In this paper, a comprehensive study of interleaving phenomenon and discussion on numerous interleavers is presented. Also, the BER performance of interleavers using IDMA scheme is displayed

Relation of Particle Size with Toxicity of Calcite Particles

The importance of certain types of nanomaterials and mineral nanoparticles, namely clays and the smallest mineral colloids, has been known for a long time. Mineral nanoparticles also behave differently than larger micro and macroscopic crystals of the same mineral. The variations in chemical properties are most likely due to differences in surface and near surface atomic structure, as well as crystal shape and surface topography as a function of size in this smallest of size regimes. Although most of the nanotoxicological studies were performed using unrealistic exposure conditions. Knowledge about potential human and environmental exposure combined with dose response, toxicity information will be necessary to determine real or perceived risks of nanomaterials following inhalation, oral or dermal routes of exposure. Because the respiratory tract is the major portal of entry for airborne nanoparticles, this exposure route can be used as an example to discuss some key concepts of nanotoxicology, including the significance of dose, dose rate, dose metric and biokinetics

Optimizing Guideline-directed Medical Therapies for Heart Failure with Reduced Ejection Fraction During Hospitalization

Heart failure remains a huge societal concern despite medical advancement, with an annual direct cost of over $30 billion. While guideline-directed medical therapy (GDMT) is proven to reduce morbidity and mortality, many eligible patients with heart failure with reduced ejection fraction (HFrEF) are not receiving one or more of the recommended medications, often due to suboptimal initiation and titration in the outpatient setting. Hospitalization serves as a key point to initiate and titrate GDMT. Four evidence-based therapies have clinical benefit within 30 days of initiation and form a crucial foundation for HFrEF therapy: renin-angiotensin-aldosterone system inhibitors with or without a neprilysin inhibitor, β-blockers, mineralocorticoid-receptor-antagonists, and sodium-glucose cotransporter-2 inhibitors. The authors present a practical guide for the implementation of these four pillars of GDMT during a hospitalization for acute heart failure

Biological predictors of chemotherapy-induced peripheral neuropathy (CIPN): MASCC neurological complications working group overview.

Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating condition associated with a number of chemotherapeutic agents. Drugs commonly implicated in the development of CIPN include platinum agents, taxanes, vinca alkaloids, bortezomib, and thalidomide analogues. As a drug response can vary between individuals, it is hypothesized that an individual's specific genetic variants could impact the regulation of genes involved in drug pharmacokinetics, ion channel functioning, neurotoxicity, and DNA repair, which in turn affect CIPN development and severity. Variations of other molecular markers may also affect the incidence and severity of CIPN. Hence, the objective of this review was to summarize the known biological (molecular and genomic) predictors of CIPN and discuss the means to facilitate progress in this field

Analyzing W.B. Yeats Selected Poetry Through Feminist Epistemology: A Reassessment

W.B. Yeats stands out as one of the most influential poets of the twentieth century. His symbolic poetry and his political and philosophical ideas are all prominently reflected in his work. During his lifetime, he was deeply influenced by a few remarkable women who made significant contributions to his poetic development and played a pivotal role in shaping his personality. Yeats's poems chosen for this study offer a profound insight into the predicament of women within various socio-cultural and economic contexts. This analysis will explore how Yeats projected female voices through multiple images and symbols in poems such as 'A Prayer for My Daughter,' 'Among School Children,' and 'Leda and the Swan.' While Maud Gonne is widely recognized as a central figure in Yeats's love poems, it's essential to acknowledge that she wasn't the sole woman who influenced the artist's evolution. Others, like Lady Gregory, Olivia Shakespeare, and George Hyde-Lees, the wife of W.B. Yeats, played significant roles in the later phase of his life, particularly in developing his philosophical treatise, "A Vision." In his final poems, Yeats attempted to convey his ultimate understanding of love, emphasizing its perfection in the unbroken relationship between the body and the mind. Works like 'Among School Children,' 'Leda and the Swan,' 'The Second Coming,' 'Sailing to Byzantium,' 'A Man Young and Old,' and many other universally acclaimed poems were inspired by his complex relationships with Maud Gonne and others

Assessing The Issues of Honour and Violence Against Women: A Human Rights Discourse Framework for The Detection of Violence Against Women

The term 'Honour Killing' is conventionally used to denote a specific category of extralegal killings where the act of murder is seen to have been motivated by pre-modern affiliations/sentiments of some sort. Acts of violence committed against people for marrying outside of caste/religion/ethnicity or other similar infringements where they are seen by their actions to have besmirched the honour of the family and the larger community come under the broad rubric of honour crime. Implicit in using the term are assumptions that mark it as different from other crimes. Honour is defined in terms of women assigned sexual and familial roles as dictated by traditional family ideology. Thus, adultery, premarital relationships (which may or may not include sexual relations), rape, and falling in love with an "inappropriate" person may constitute violations of family honour. 'Crimes of honour' as a form of violence against women does not imply that men also are not subjected to such crimes. In cases of forced marriage or interference with the right of choice and whom to marry, pressure from older family members over younger members will apply to men as well as to women. However, women remain the victims and survivors of 'crimes of honour' and have fewer available remedies

Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production

During therapy, adaptations driven by cellular plasticity are partly responsible for driving the inevitable recurrence of glioblastoma (GBM). To investigate plasticity-induced adaptation during standard-of-care chemotherapy temozolomide (TMZ), we performed in vivo single-cell RNA sequencing in patient-derived xenograft (PDX) tumors of GBM before, during, and after therapy. Comparing single-cell transcriptomic patterns identified distinct cellular populations present during TMZ therapy. Of interest was the increased expression of ribonucleotide reductase regulatory subunit M2 (RRM2), which we found to regulate dGTP and dCTP production vital for DNA damage response during TMZ therapy. Furthermore, multidimensional modeling of spatially resolved transcriptomic and metabolomic analysis in patients’ tissues revealed strong correlations between RRM2 and dGTP. This supports our data that RRM2 regulates the demand for specific dNTPs during therapy. In addition, treatment with the RRM2 inhibitor 3-AP (Triapine) enhances the efficacy of TMZ therapy in PDX models. We present a previously unidentified understanding of chemoresistance through critical RRM2-mediated nucleotide production

Reporting trends, practices, and resource utilization in neuroendocrine tumors of the prostate gland: a survey among thirty-nine genitourinary pathologists

Background: Neuroendocrine differentiation in the prostate gland ranges from clinically insignificant neuroendocrine differentiation detected with markers in an otherwise conventional prostatic adenocarcinoma to a lethal high-grade small/large cell neuroendocrine carcinoma. The concept of neuroendocrine differentiation in prostatic adenocarcinoma has gained considerable importance due to its prognostic and therapeutic ramifications and pathologists play a pivotal role in its recognition. However, its awareness, reporting, and resource utilization practice patterns among pathologists are largely unknown. Methods: Representative examples of different spectrums of neuroendocrine differentiation along with a detailed questionnaire were shared among 39 urologic pathologists using the survey monkey software. Participants were specifically questioned about the use and awareness of the 2016 WHO classification of neuroendocrine tumors of the prostate, understanding of the clinical significance of each entity, and use of different immunohistochemical (IHC) markers. De-identified respondent data were analyzed. Results: A vast majority (90%) of the participants utilize IHC markers to confirm the diagnosis of small cell neuroendocrine carcinoma. A majority (87%) of the respondents were in agreement regarding the utilization of type of IHC markers for small cell neuroendocrine carcinoma for which 85% of the pathologists agreed that determination of the site of origin of a high-grade neuroendocrine carcinoma is not critical, as these are treated similarly. In the setting of mixed carcinomas, 62% of respondents indicated that they provide quantification and grading of the acinar component. There were varied responses regarding the prognostic implication of focal neuroendocrine cells in an otherwise conventional acinar adenocarcinoma and for Paneth cell-like differentiation. The classification of large cell neuroendocrine carcinoma was highly varied, with only 38% agreement in the illustrated case. Finally, despite the recommendation not to perform neuroendocrine markers in the absence of morphologic evidence of neuroendocrine differentiation, 62% would routinely utilize IHC in the work-up of a Gleason score 5 + 5 = 10 acinar adenocarcinoma and its differentiation from high-grade neuroendocrine carcinoma. Conclusion: There is a disparity in the practice utilization patterns among the urologic pathologists with regard to diagnosing high-grade neuroendocrine carcinoma and in understanding the clinical significance of focal neuroendocrine cells in an otherwise conventional acinar adenocarcinoma and Paneth cell-like neuroendocrine differentiation. There seems to have a trend towards overutilization of IHC to determine neuroendocrine differentiation in the absence of neuroendocrine features on morphology. The survey results suggest a need for further refinement and development of standardized guidelines for the classification and reporting of neuroendocrine differentiation in the prostate gland